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Fuel cells, also known as flow batteries, hold great promise for generation of electricity in previously unimaginable ways, but rely upon platinum catalysts to do so.  Biological fuel cells (BFCs) use organic catalysts (enzymes) and fuels and are able to derive electricity from nearly any biological process.  Two major factors have been identified influencing the suitability of a laccase enzyme for BFC applications: the REDOX potential of the T1 copper site (determined by the AA residues at the T1 site) and the ability of the enzyme to be secreted (determined by the number of N-glycosylation sites).  Applications include a suite of self-powered implanted medical devices, wastewater treatment plants, and biosensors as well as low-cost remote power generation from waste materials.   

Concept map: 

Link to GitHub Repo:


Working File Full:

Test Seqs (Fusarium, Trametes, Pleurotus):

All NCBI Laccase Protein Seqs:


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