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Step 2 -  Create submission package folders and add compressed sequence files.  The submission package is created using tools in the DE.  Submission Packages have three levels: BioProject, BioSample, Library.  Package organization is similar to the SRA organization detailed in the NCBI Quick Start Guide.  Within the DE data and metadata for SRA-defined ‘Experiments’ and ‘Runs’ are part of the ‘Library level of the submission package’.